Whammy

Noun

 * 1) a serious or devastating setback
 * 2) an evil spell; a curse or hex

Thesaurus
Jonah, amulet, anathema, bad blood, bad influence, bad temper, bad will, ban, bedroom eyes, blasphemy, blighting glance, bring bad luck, cantrip, charm, come-hither look, commination, curse, damnation, denunciation, enchantment, evil disposition, evil eye, evil genius, evil star, excommunication, execration, exorcism, fetish, fulmination, fylfot, gammadion, gape, gaze, glad eye, glamour, glare, glower, glowering look, goggle, good-luck charm, hex, hoodoo, ill nature, ill will, ill wind, ill-disposedness, imprecation, jinx, juju, love charm, lucky bean, lucky piece, madstone, magic spell, malevolence, malevolent influence, malison, malocchio, mascot, mumbo jumbo, obeah, ogle, penetrating look, periapt, philter, phylactery, proscription, scarab, scarabaeus, scarabee, spell, stare, sudarium, swastika, talisman, thundering, veronica, voodoo, wanga, weird

Derived terms

 * double whammy
 * triple whammy