Downer

Noun

 * 1) A negative drug trip.
 * Normally those pills give me a boost, but last night they gave me a downer
 * 1) A drug that has depressive qualities.
 * 2) Something or someone disagreeable, dispiriting or depressing; a killjoy
 * 3) * 2009,, 
 * You don't really need to know me. I'm kind of a downer.

Thesaurus
Amytal, Amytal pill, Demerol, Dolophine, H, Luminal, Luminal pill, M, Mickey Finn, Nembutal, Nembutal pill, Schmerz, Seconal, Seconal pill, Slough of Despond, Tuinal, Tuinal pill, adverse circumstances, adversity, affliction, aggravation, alcohol, amobarbital sodium, analgesic, annoyance, anodyne, bad news, barb, barbiturate, barbiturate pill, bedevilment, black stuff, blank despondency, blight, blue, blue angel, blue devil, blue heaven, blue velvet, bore, bother, botheration, bothersomeness, bummer, calmative, care, chloral hydrate, codeine, codeine cough syrup, crashing bore, cross, curse, death wish, dejectedness, dejection, depressant, depression, depressor, despair, despondency, despondentness, devilment, difficulties, difficulty, discouragement, disheartenment, dispiritedness, dogging, dolly, down trip, downcastness, downheartedness, drag, drooping spirits, exasperation, goofball, harassment, hard knocks, hard life, hard lot, hard stuff, hardcase, hardship, harrying, headache, heartlessness, heroin, hop, hopelessness, horse, hounding, hypnotic, irritation, junk, knockout drops, laudanum, liquor, lotus, low spirits, lowness, lowness of spirit, malaise, meperidine, methadone, molestation, morphia, morphine, narcotic, nuisance, opiate, opium, oppression, pacifier, pain killer, paregoric, pen yan, persecution, pessimism, pest, phenobarbital, phenobarbital sodium, plight, predicament, pressure, problem, purple heart, quietener, rainbow, red, rigor, scag, sea of troubles, secobarbital sodium, sedative, self-destructive urge, shit, sinking heart, sleep-inducer, sleeper, sleeping draught, sleeping pill, smack, sodium thiopental, somnifacient, soother, soothing syrup, soporific, spiritlessness, stress, stress of life, suicidal despair, taedium vitae, tar, tranquilizer, trial, tribulation, trouble, troubles, turps, vale of tears, vexation, vexatiousness, vicissitude, weariness of life, white stuff, worriment, worry, yellow, yellow jacket

Anagrams

 * wonder, Wonder