Ruination

Noun

 * 1) The state of being ruined, a state of devastation or destruction.
 * 2) The act of ruining or wrecking.
 * 3) The cause of being ruined, destroyed or lost.
 * 4) A loss of reputation.

Thesaurus
bane, bankruptcy, bloodbath, blue ruin, breakage, breakdown, breakup, carnage, collapse, confusion, consumption, crack-up, crippling, damage, damnation, decimation, depredation, desolation, despoilment, despoliation, destroyer, destruction, detriment, devastation, dilapidation, disablement, disintegration, disorganization, disrepair, disruption, dissolution, encroachment, harm, havoc, hecatomb, hobbling, holocaust, hurt, hurting, impairment, incapacitation, infringement, injury, inroad, loss, maiming, mayhem, mischief, mutilation, perdition, ravage, ruin, ruinousness, sabotage, scathe, shambles, sickening, slaughter, spoiling, spoliation, undoing, vandalism, waste, weakening, wrack, wrack and ruin, wreck

Anagrams

 * urination