Vicissitude

Noun

 * 1) Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.
 * 2)  a change, especially in one's life or fortunes.

Synonyms

 * ups and downs

Thesaurus
adverse circumstances, adversity, affliction, aggravation, alteration, alternation, annoyance, asperity, blight, bummer, care, chain of circumstances, chain reaction, change, changeability, changes, chapter of accidents, chop and change, concatenation of events, contrasts, cross, curse, difficulties, difficulty, diversity, downer, feast and famine, fluctuation, flukiness, flux, hard knocks, hard life, hard lot, hardcase, hardness, hardship, inconstancy, innovation, ins and outs, irritation, mischance, misfortune, mutability, mutation, novelty, oscillation, pendulation, permutation, plight, predicament, pressure, progression, reversal, rigor, sea of troubles, seesawing, shifting, shuffling, sport, stress, stress of life, teeter-tottering, teetering, tottering, transposition, trial, tribulation, trouble, troubles, unpredictability, ups and downs, vacillation, vale of tears, variability, variation, variations, variety, vicious circle, vicissitudes, vicissitudes of fortune, wavering